Jeff Weaver smacked a RBI double and pitched well for six innings in a 12-2 win over the Milwaukee Brewers at Miller Park on Tuesday.
The Cardinals reduced their magic number for clinching the NL Central for a third straight season to six.
Isringhausen, who has 33 saves, will have arthroscopic surgery on his arthritic left hip on Sept. 21. Isringhausen, who has 10 blown saves this season, has not pitched since Sept. 6, and did not make the trip to Milwaukee.
“He’s the anchor of that bullpen out there, and it’s an unfortunate situation, but we are blessed with a lot of good arms out there,” Weaver (7-14) said.
The 34-year-old Isringhausen, the Cardinals’ all-time saves leader, will begin physical therapy within several days of the surgery, but the team said no timetable has been set for his return. Right-handers Braden Looper and Adam Wainwright are expected to handle the closer duties.
Aaron Miles had four hits and three RBIs for the Cardinals, while Ronnie Belliard had three hits, including a homer, and scored four runs.